Methylcobalamin, Nortriptyline and Pregabalin Tablets

Methylcobalamin, Nortriptyline and Pregabalin Tablets with the brand name “D-COB NM” are a fixed-dose combination drug that is used to treat diabetic peripheral neuropathy pain and postherpetic neuralgia pain. Neuropathic pain is a progressive nerve disease characterised by chronic, persistent pain, which results in pain from damaged nerves or a dysfunctional nervous system. The features are spontaneous, unprovoked pain, unpleasant sensation, shooting, burning or stinging pain, and evoked pain (pain that is triggered by events normally not painful).

Methylcobalamin, Nortriptyline and Pregabalin Tablets are a blend of three medicines: Methylcobalamin (vitamin), Nortriptyline (antidepressant), and Pregabalin (anti-convulsant). Methylcobalamin is a vitamin which helps in making myelin, a substance which guards nerve fibres and repairs injured nerve cells. Nortriptyline functions by raising the level of nerve transmitters (serotonin and noradrenaline) in the brain, which lessens the pain signals reaching the brain. Pregabalin decreases pain by blocking messages going through the brain and down the spine. Altogether, it is used to treat neuropathic pain.

Medical Benefits

• It is used for the treatment of neuropathic pain due to diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury, etc.
• Methylcobalamin helps to synthesise myelin, a substance that insulates nerve fibres and restores injured nerve cells.
• Nortriptyline operates by elevating the nerve transmitters (serotonin and noradrenaline) in the brain, and this blocks the pain messages from coming into the brain.
• Pregabalin lowers pain by disrupting pain messages passing through the brain and down the spinal cord. It, together, treats neuropathic pain.

Directions For Use

• Swallow Methylcobalamin, Nortriptyline and Pregabalin Tablets whole with water.
• Do not crush, chew or break it.
• Take the drug daily at the same time to maintain levels in your body.
• Take the tablet with food if you are instructed to do so, to avoid an upset stomach.
• Do not skip or take double the dose if you forget to take one.

Storage

• Never store it where children can get to prevent any mishap.
• Store it where the capsules are in sealed packs and not exposed to heat or light on a shelf.
• The tablet needs to be closed once used to guarantee the quality of supplements.

Precautions

• It can interact with antidepressant drugs (e.g. duloxetine, sertraline, escitalopram), pain killer drugs (e.g. codeine, hydrocodone, morphine, oxycodone, tramadol, acetaminophen), and anti-convulsant drugs (e.g. topiramate).
• Do not drink alcohol while on Methylcobalamin+nortriptyline+pregabalin, as it may lead to excessive drowsiness and drowsiness.
• Take this medication with medical supervision if you have experienced anticholinergic effects, cardiovascular disease, pheochromocytoma, recovery of acute myocardial infarction, cardiovascular disease, depression, seizure disorders, etc.
• Do not take Methylcobalamin, Nortriptyline and Pregabalin Tablets if you are pregnant unless instructed by your physician.
• It leads to drowsiness, sleepiness and blurred vision. Don’t drive or use machinery unless you are alert.
• It must not be given to children without the doctor’s advice.

Side Effects

• Feeling sleepy, tired or dizzy
• Constipation
• Diarrhoea
• Dry mouth
• Headache

Frеquеntly Askеd Quеstions (FAQs)

Can I stop taking this medicine at any time?

No, don’t stop without consulting your doctor because it can lead to withdrawal issues.

Can this tablet lead to swelling?

Yes, it may cause swelling of the hands and legs. To avoid it, do not sit or stand for a long time and elevate your legs while resting.

Is this a painkiller?

No, it is not a painkiller, but it does regulate nerve pain due to conditions such as diabetic neuropathy.

How to control weight gain due to this medicine?

Eat healthy food rich in fibre and protein, do not consume junk food, do some exercise regularly, and monitor your weight frequently.

Can this medicine make me drowsy or get me dizzy?

Yes, so don’t drive or operate machines unless you are completely awake.

Will it affect my sexual health?

Occasionally, it can reduce sex drive or cause issues such as difficulty with an erection. Speak with your physician if this occurs.

Are there allergic reactions?

Occasionally, some individuals will experience rash, itching, swelling, or shortness of breath. Contact medical assistance if this occurs.